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Neural Foundry's avatar

This investigation into the oral-brain axis is incredibly valuable for caregivers and patients alike. The Cortexyme trial failure actually highlights something important about single-pathway interventions whe bacterial translocation through the BBB might be just one piece of a multifactorial process. I've been more diligent about flossing since reading similar research, honestly seems like such a simple preventative step.

Greg Rowland's avatar

Thanks for commenting. I am trying to understand "bacterial translocation through the BBB might be just one piece of a multifactorial process).

I know that Alzheimer's is not a single bacterial invasion of the BBB. It can be several things, like reduced production of short-chain fatty acids. Do all of these factors damage the BBB?

Am I understanding this correctly?

Lisa Freeman's avatar

This is fascinating, and a little concerning, as I see more gingivitis among young people more than I ever did as a young person myself. The waterpik is my friend now, and I wish I'd discovered it much earlier in life.

Greg Rowland's avatar

I agree. Bring on the waterpik!